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Development of phenol-grafted polyglucuronic acid and its application to extrusion-based bioprinting inks

Abstract : In this present work, we developed a phenol grafted polyglucuronic acid (PGU) and investigated the usefulness in tissue engineering field by using this derivative as a bioink component allowing gelation in extrusion-based 3D bioprinting. The PGU derivative was obtained by conjugating with tyramine, and the aqueous solution of the derivative was curable through a horseradish peroxidase (HRP)-catalyzed reaction. From 2.0 w/v% solution of the derivative containing 5 U/mL HRP, hydrogel constructs were successfully obtained with a good shape fidelity to blueprints. Mouse fibroblasts and human hepatoma cells enclosed in the printed constructs showed about 95% viability the day after printing and survived for 11 days of study without a remarkable decrease in viability. These results demonstrate the great potential of the PGU derivative in tissue engineering field especially as an ink component of extrusion-based 3D bioprinting.
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https://hal-u-picardie.archives-ouvertes.fr/hal-03609608
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Soumis le : mardi 15 mars 2022 - 16:44:17
Dernière modification le : mercredi 21 septembre 2022 - 15:14:05

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Shinji Sakai, Takashi Kotani, Ryohei Harada, Ryota Goto, Takahiro Morita, et al.. Development of phenol-grafted polyglucuronic acid and its application to extrusion-based bioprinting inks. Carbohydrate Polymers, Elsevier, 2022, 277, ⟨10.1016/j.carbpol.2021.118820⟩. ⟨hal-03609608⟩

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