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Graphene quantum dots: From efficient preparation to safe renal excretion

Abstract : Carbon nanomaterials offer excellent prospects as therapeutic agents, and among them, graphene quantum dots (GQDs) have gained considerable interest thanks to their aqueous solubility and intrinsic fluorescence, which enable their possible use in theranostic approaches, if their biocompatibility and favorable pharmacokinetic are confirmed. We prepared ultra-small GQDs using an alternative, reproducible, top-down synthesis starting from graphene oxide with a nearly 100% conversion. The materials were tested to assess their safety, demonstrating good biocompatibility and ability in passing the ultrafiltration barrier using anin vitromodel. This leads to renal excretion without affecting the kidneys. Moreover, we studied the GQDsin vivobiodistribution confirming their efficient renal clearance, and we demonstrated that the internalization mechanism into podocytes is caveolae-mediated. Therefore, considering the reported characteristics, it appears possible to vehiculate compounds to kidneys by means of GQDs, overcoming problems related to lysosomal degradation.
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https://hal-u-picardie.archives-ouvertes.fr/hal-03613482
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Soumis le : vendredi 18 mars 2022 - 14:52:54
Dernière modification le : vendredi 1 avril 2022 - 03:58:02

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Caroline Hadad, Jose Miguel Gonzalez-Dominguez, Silvia Armelloni, Deborah Mattinzoli, Masami Ikehata, et al.. Graphene quantum dots: From efficient preparation to safe renal excretion. Nano Research, 2021, 14 (3), pp.674-683. ⟨10.1007/s12274-020-3096-y⟩. ⟨hal-03613482⟩

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