Feasibility, Prediction and Association of Right Ventricular Free Wall Longitudinal Strain with 30-Day Mortality in Severe COVID-19 Pneumonia: A Prospective Study. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Clinical Medicine Année : 2022

Feasibility, Prediction and Association of Right Ventricular Free Wall Longitudinal Strain with 30-Day Mortality in Severe COVID-19 Pneumonia: A Prospective Study.

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Alexis Hermida
Thomas Booz
  • Fonction : Auteur
Maxime Crombet
  • Fonction : Auteur
Pierre Huette
  • Fonction : Auteur
Osama Abou-Arab
Yazine Mahjoub
Christophe Beyls
  • Fonction : Auteur
Tristan Ghesquières
  • Fonction : Auteur

Résumé

INTRODUCTION: Right ventricular (RV) systolic dysfunction (RVsD) is a common complication of coronavirus infection 2019 disease (COVID-19). The right ventricular free wall longitudinal strain parameter (RV-FWLS) is a powerful predictor of mortality. We explored the performance of RVsD parameters for predicting 30-day mortality and the association between RV-FWLS and 30-day mortality. METHODS: COVID-19 patients hospitalized at Amiens University Hospital in the critical care unit with transthoracic echocardiography were included. We measured tricuspid annular plane systolic excursion (TAPSE), the RV S' wave, RV fractional area change (RV-FAC), and RV-FWLS. The diagnostic performance of RVsD parameters as predictors for 30-day mortality was evaluated by the area under the receiver operating characteristic (ROC) curve (AUC). RVsD was defined by an RV-FWLS < 21% to explore the association between RVsD and 30-day mortality. RESULTS: Of the 116 patients included, 20% (n = 23/116) died and 47 had a RVsD. ROC curve analysis showed that RV-FWLS failed to predict 30-day mortality, as did conventional RV parameters (all p > 0.05). TAPSE (21 (19-26) mm vs. 24 (21-27) mm; p = 0.024) and RV-FAC (40 (35-47)% vs. 47 (41-55)%; p = 0.006) were lowered in the RVsD group. In Cox analysis, RVsD was not associated with 30-day mortality (hazard ratio = 1.12, CI 95% (0.49-2.55), p = 0.78). CONCLUSION: In severe COVID-19 pneumonia, RV-FWLS was not associated with 30-day mortality.

Dates et versions

hal-03723435 , version 1 (14-07-2022)

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Alexis Hermida, Thomas Booz, Maxime Crombet, Nicolas Martin, Pierre Huette, et al.. Feasibility, Prediction and Association of Right Ventricular Free Wall Longitudinal Strain with 30-Day Mortality in Severe COVID-19 Pneumonia: A Prospective Study.. Journal of Clinical Medicine, 2022, 11 (13), ⟨10.3390/jcm11133629⟩. ⟨hal-03723435⟩
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