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Prevalence of Post-Acute COVID-19 Symptoms Twelve Months after Hospitalisation in Participants Retained in Follow-up: Analyses Stratified by Gender from a Large Prospective Cohort.

Jade Ghosn 1 Delphine Bachelet 2, 3, 1 Marine Livrozet 4, 5, 6, 7 Minerva Cervantes-Gonzalez 3, 1 Julien Poissy 8 François Goehringer 9 Charlotte Salmon Gandonniere 10 Mylène Maillet 11 Firouzé Bani-Sadr 12 Guillaume Martin-Blondel 13 Pierre Tattevin 14, 15, 16 Odile Launay 17 Laure Surgers 18 Emmanuel Dudoignon 19, 20, 21 Geoffroy Liegeon 22 David Zucman 23 Cédric Joseph 24 Eric Senneville 25 Cécile Yelnik 26 Pierre-Marie Roger 27, 28 Karine Faure 29 Marie Gousseff 30 André Cabié 31, 32, 33 Xavier Duval 34, 35 Catherine Chirouze 36 Cedric Laouénan 2, * 
* Auteur correspondant
Abstract : OBJECTIVES: Persistent post-acute COVID-19 symptom (PACS) have been reported up to 6-months (M6) after hospital discharge. Here we assessed, in the longitudinal prospective national French COVID cohort, symptoms that persisted 12-months (M12) after admission for COVID-19. METHODS: Hospitalized patients with a virologically-confirmed COVID-19 were enrolled. Follow-up was planned until M12 post-admission. Associations between persistence of ≥q3 PACS at M12 and clinical characteristics at admission were assessed through logistic regression according to gender. RESULTS: We focused on participants enrolled between January 24(th) and July 15(th) 2020, in order to allow M12 follow-up. M12 data were available for 737 participants. Median age was 61~years, 475 (64%) were men and 242/647 (37%) were admitted to ICU during the acute phase. At M12, 194/710 (27%) of participants had ≥q3 persistent PACS, mostly fatigue, dyspnea and joint pain. Among those who had a professional occupation before the acute phase 91/339 (27%) were still on sick leave at M12. Presence of ≥q3 persistent PACS was associated with female gender, both anxiety and depression, impaired health-related quality of life (HRQL) and mMRC scale <57. Compared to men, women more often reported presence of >3 persistent PACS (98/253, 39% vs 96/457, 21%), depression and anxiety (18/152, 12% vs 17/268, 6% and 33/156, 21% vs 26/264, 10%, respectively), impaired physical HRQL (76/141, 54% vs 120/261, 46%). Women had less often returned to work than men (77/116, 66% vs 171/223, 77%). CONCLUSIONS: A fourth of individuals admitted to hospital for COVID-19 still had ≥q3 persistent PACS at M12 post-discharge. Women reported more often ≥q3 persistent PACS, suffered more from anxiety and depression, and had less often returned to work than men.
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https://hal-u-picardie.archives-ouvertes.fr/hal-03801797
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Soumis le : jeudi 6 octobre 2022 - 18:20:13
Dernière modification le : mardi 6 décembre 2022 - 12:42:14

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Jade Ghosn, Delphine Bachelet, Marine Livrozet, Minerva Cervantes-Gonzalez, Julien Poissy, et al.. Prevalence of Post-Acute COVID-19 Symptoms Twelve Months after Hospitalisation in Participants Retained in Follow-up: Analyses Stratified by Gender from a Large Prospective Cohort.. Clinical Microbiology and Infection, 2022, pp.S1198-743X(22)00507-9. ⟨10.1016/j.cmi.2022.08.028⟩. ⟨hal-03801797⟩

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