Synthesis of novel S - and O -disaccharide analogs of heparan sulfate for heparanase inhibition

D. S.-E. Koffi Teki , B. Coulibaly (1, 2) , A. Bil , Aurélie Vallin (1) , David Lesur (1) , B. Fanté , Vincent Chagnault (1) , José Kovensky (1)

1 LG2A - Laboratoire de Glycochimie, des Antimicrobiens et des Agro-ressources - UMR CNRS 7378
2 UFHB - Université Félix Houphouët-Boigny

Design and synthesis of the first sulfated thiodisaccharide, analog of a heparane sulfate sequence, which is able to inhibit heparanase with an IC 50 in the micromolar range.

Domaines: Chimie

D. S.-E. Koffi Teki, B. Coulibaly, A. Bil, Aurélie Vallin, David Lesur, et al.. Synthesis of novel S - and O -disaccharide analogs of heparan sulfate for heparanase inhibition. Organic & Biomolecular Chemistry, 2022, 20 (17), pp.3528-3534. ⟨10.1039/d2ob00250g⟩. ⟨hal-03832485⟩