Water-mediated synthesis of disubstituted 5-aminopyrimidines from vinyl azides under microwave irradiation

Oussama Dehbi (1) , Esam Ishak , Mohammed Bakht , Mohammed Geesi (2) , Mohammed Alshammari , Vincent Chagnault (3) , Abdellah Kaiba (4) , Saïd Lazar (5) , Yassine Riadi (6)

1 Department of Chemistry
2 Department of Chemistry
3 LG2A - Laboratoire de Glycochimie, des Antimicrobiens et des Agro-ressources - UMR CNRS 7378
4 Department of Physics
5 Laboratoire de biochimie, environnement et agroalimentaire, URAC 36, FSTM, Université Hassan II Casablanca
6 College of Pharmacy

An efficient and ecofriendly method for the synthesis of disubstituted 5-aminopyrimidines from vinyl azides and urea or thiourea was developed. This reaction proceeds under microwave irradiation conditions in the presence of water as a solvent. The remarkable features of this new protocol are high conversion, short reaction times, cleaner reaction profiles and straightforward procedure.

Domaines: Chimie

Oussama Dehbi, Esam Ishak, Mohammed Bakht, Mohammed Geesi, Mohammed Alshammari, et al.. Water-mediated synthesis of disubstituted 5-aminopyrimidines from vinyl azides under microwave irradiation. Green chemistry letters and reviews, 2018, 11 (2), pp.62-66. ⟨10.1080/17518253.2018.1437225⟩. ⟨hal-03613795⟩